Louise Creagh

Associate Professor of Teaching

Office: CHBE 403

Email: louise.creagh@ubc.ca

Research Summary

Thermodynamics and kinetics of protein stability and protein-ligand binding


University of California, Berkeley, 1992, Ph.D.

University of California, Berkeley, 1985, M.S.

University of Alberta, 1983, B.A.Sc.

Research interests + projects

Dr. Creagh research interests include thermodynamics and kinetics (calorimetry, analytical ultracentrifugation, surface plasmon resonance) of protein stability and protein-ligand binding.

Scholarly and professional activities + affiliations

Michael Smith Laboratories

Selected publications + presentations

K.-S. Pi, D.Bortolotti, Y.Sang, G.Schiuma, S.Beltrami, S.Rizzo, A.Bortoluzzi, E.Baldi, A.L.Creagh, C.A.Haynes, R.Rizzo, S.K. Straus, “Studying the Interactions of U24 from HHV-6 in Order to Further Elucidate Its Potential Role in MS” Viruses, 14 (11) 2384-2408  (2022).

G. Déjean, A. S. Tauzin, S. W. Bennett, A. L. Creagh, H. Brumer, “Adaptation of Syntenic Xyloglucan Utilization Loci of Human Gut Bacteroidetes to Polysaccharide Side Chain Diversity”, Appl. Environ. Microbiol., 85 (20) (2019).

M.T. Kalathottukaren, S. Abbina, K.Yu, R.A. Shenoi, A.L.Creagh, C.A. Haynes, J.N. Kizhakkedathu, “A polymer therapeutic having universal heparin reversal activity: molecular design and functional mechanism”, Biomacromolecules, 18 (10) 3343–3358 (2017).

J.F. Cawthray, D.M. Weeks, O. Sivak, A.L. Creagh, F. Ibrahim, M. Iafrate, C.A. Haynes, K.M. Wasan, C. Orvig, “In vivo study and thermodynamic investigation of two lanthanum complexes, La(dpp)3 and La(XT), for the treatment of bone resorption disorders”, Chem. Sci. 6 6439-6447 (2015).

J.Larsbrink, T.E. Rogers, G.R. Hemsworth, L.S. McKee, A.S. Tauzin, O. Spadiut, S. Klinter, N.A. Pudlo, K. Urs, N.M. Koropatkin, A.L. Creagh, C.A. Haynes, A.G. Kelly, S.N.Cederholm, G.L. Davies, E.C. Martens, H. Brumer, “A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes”, Nature 506 498-502 (2014).